Microsoft has excellent backward compatibility, and still runs programs from the 90’s, so I’ve no reasons to suspect that Clarion programs won’t run. I can’t imagine that they’ve decided to somehow break existing win32 apps and expect the market to respond well.
That said, IE (which was deprecated some time ago) will apparently not be included. I can only assume this means the IE control will no longer be there either. This would mean that programs using the File Explorer IE control (or anything else that uses the IE control) would lose that functionality.
The replacement to use is Chrome Explorer (https://www.capesoft.com/accessories/chromeexplorersp.htm) - which has been out for some time now. This replaces the IE control with a Chromium control, and you distribute that, so there’s no dependence on anything in the OS.